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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IMPDH2
All Species:
47.58
Human Site:
Y289
Identified Species:
87.22
UniProt:
P12268
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P12268
NP_000875.2
514
55805
Y289
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
Chimpanzee
Pan troglodytes
XP_516452
608
66107
Y359
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
Rhesus Macaque
Macaca mulatta
XP_001110855
514
55766
Y289
F
Q
I
N
M
I
K
Y
I
K
E
K
Y
P
N
Dog
Lupus familis
XP_850933
514
55841
Y289
F
Q
I
N
M
I
K
Y
I
K
E
K
Y
P
T
Cat
Felis silvestris
Mouse
Mus musculus
P24547
514
55797
Y289
F
Q
I
N
M
I
K
Y
I
K
E
K
Y
P
S
Rat
Rattus norvegicus
NP_954530
514
55780
Y289
F
Q
I
N
M
I
K
Y
I
K
E
K
Y
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505397
665
73137
Y440
F
Q
I
N
M
I
K
Y
I
K
E
K
Y
H
N
Chicken
Gallus gallus
NP_001025772
514
55540
Y289
F
Q
I
N
M
I
K
Y
I
K
E
K
Y
P
N
Frog
Xenopus laevis
NP_001082410
514
55431
Y289
F
Q
I
N
M
I
K
Y
I
K
E
K
Y
P
D
Zebra Danio
Brachydanio rerio
NP_958872
514
55692
Y289
F
Q
I
N
M
I
K
Y
I
K
E
K
Y
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07152
537
57811
Y308
Y
Q
V
E
M
I
K
Y
I
K
E
T
Y
P
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SA34
502
54033
Y279
Y
Q
L
E
M
I
K
Y
V
K
N
T
Y
P
E
Baker's Yeast
Sacchar. cerevisiae
P50094
524
56375
W294
F
Q
L
N
M
I
K
W
I
K
E
T
F
P
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.5
99.6
99.4
N.A.
98.8
98.4
N.A.
72.9
94.9
92.8
91.2
N.A.
64.9
N.A.
N.A.
N.A.
Protein Similarity:
100
84.5
99.8
99.6
N.A.
99.6
98.8
N.A.
75.1
97
95.3
95.9
N.A.
79.8
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
86.6
N.A.
86.6
93.3
N.A.
86.6
93.3
86.6
93.3
N.A.
60
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
93.3
100
100
100
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
47.8
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
65.7
77.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
93.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
16
% D
% Glu:
0
0
0
16
0
0
0
0
0
0
77
0
0
0
16
% E
% Phe:
85
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
77
0
0
100
0
0
93
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
100
0
0
100
0
77
0
0
0
% K
% Leu:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
100
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
85
0
0
0
0
0
0
8
0
0
0
54
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
93
0
% P
% Gln:
0
100
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
24
0
0
8
% T
% Val:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
16
0
0
0
0
0
0
93
0
0
0
0
93
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _